{"id":15977,"date":"2024-03-12T23:54:35","date_gmt":"2024-03-12T22:54:35","guid":{"rendered":"https:\/\/francelyme.fr\/site\/?p=15977"},"modified":"2024-03-29T19:04:37","modified_gmt":"2024-03-29T18:04:37","slug":"le-long-covid-ressemble-exactement-et-je-veux-dire-exactement-a-lyme-chronique","status":"publish","type":"post","link":"https:\/\/francelyme.fr\/site\/le-long-covid-ressemble-exactement-et-je-veux-dire-exactement-a-lyme-chronique\/","title":{"rendered":"\u00ab\u00a0Le long Covid ressemble exactement, et je veux dire exactement, \u00e0 Lyme chronique\u00a0\u00bb"},"content":{"rendered":"
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Le covid \u00e0 long terme et la maladie de Lyme chronique sont \u00e9tonnamment similaires. Michal Tal, immuno-ing\u00e9nieur du MIT, est sur l’affaire.<\/p>\n\n\n\n

MIT Technology Review est un magazine bimensuel appartenant au Massachusetts Institute of Technology dont les th\u00e9matiques principales sont la science et la technologie.<\/p>\n\n\n\n

Son dernier num\u00e9ro pr\u00e9sente les travaux de Michal Tal, anciennement de Stanford, aujourd’hui du MIT.<\/p>\n\n\n\n

Elle a commenc\u00e9 par \u00e9tudier les r\u00e9ponses immunitaires au cancer, puis a \u00e9tudi\u00e9 la maladie de Lyme. Comme l’article le d\u00e9crit :<\/p>\n\n\n\n

En 2020, la pand\u00e9mie a frein\u00e9 la plupart des recherches en personne \u00e0 Stanford, y compris les \u00e9tudes de Tal sur Lyme, et elle s’est tourn\u00e9e vers l’\u00e9tude de la r\u00e9ponse immunitaire salivaire au covid\u2026 Pour Tal, les similitudes avec la maladie de Lyme \u00e9taient \u00e9tranges. \u00abLe long covid ressemble exactement, et je veux dire exactement, \u00e0 la maladie de Lyme chronique\u00bb, dit-elle. \u00ab L\u2019un est caus\u00e9 par une bact\u00e9rie et l\u2019autre est caus\u00e9 par un virus. Et j\u2019ai commenc\u00e9 \u00e0 me poser cette question : est-ce que le chemin que vous avez emprunt\u00e9 pour rejoindre Rome est important ? Ou est-ce que \u00e7a compte seulement que tu sois \u00e0 Rome ?\u00a0\u00bb<\/p><\/blockquote>\n\n\n\n

En fait, Tal a d\u00e9j\u00e0 identifi\u00e9 une piste convaincante : les niveaux de plusieurs types d\u2019anticorps, dont les IgG et les IgE, au d\u00e9but de l\u2019infection. Elle caract\u00e9rise les diff\u00e9rents sous-types d\u2019IgG comme l\u2019\u00e9quipe SWAT du syst\u00e8me immunitaire \u2013 une petite attaque cibl\u00e9e qui laisse intact le voisinage environnant. Les IgE, en revanche, ressemblent \u00e0 une frappe a\u00e9rienne. Il \u00e9limine les agents pathog\u00e8nes mais cause \u00e9galement de graves dommages \u00e0 l\u2019organisme. \u00abLes IgE sont destin\u00e9es \u00e0 remodeler les tissus\u00bb, explique Tal. \u00ab\u00a0Le remodelage des tissus est co\u00fbteux et douloureux, et beaucoup de choses peuvent mal se passer lorsque vous le faites de cette fa\u00e7on.\u00a0\u00bb<\/p><\/blockquote>\n\n\n\n

Aujourd\u2019hui, les tests de Lyme examinent uniquement les IgG et un autre type d\u2019anticorps, les IgM, mais pas les IgE. \u00ab Nous ignorons ceux qui ont r\u00e9agi aux frappes a\u00e9riennes \u00bb, dit Tal. Le suivi des niveaux d\u2019IgE, d\u2019IgG et d\u2019autres anticorps peut \u00eatre la cl\u00e9 pour pr\u00e9dire quelles infections de Lyme se transformeront en maladie chronique. En juillet, les National Institutes of Health ont accord\u00e9 \u00e0 Tal 2 millions de dollars pour tester davantage cette boule de cristal immunologique. Elle et son \u00e9quipe pr\u00e9voient de publier leurs r\u00e9sultats d\u00e8s 2025.<\/p><\/blockquote>\n\n\n\n

La subvention du NIH, l’une des nombreuses subventions destin\u00e9es \u00e0 la recherche sur la maladie de Lyme chronique, signale un changement dans la fa\u00e7on dont l’\u00e9tablissement m\u00e9dical per\u00e7oit ces patients. L\u2019apparition explosive de millions de long-courriers du Covid, dont beaucoup sont des m\u00e9decins et des infirmi\u00e8res, a boulevers\u00e9 les croyances bien ancr\u00e9es sur les maladies chroniques d\u00e9clench\u00e9es par une infection, \u00e0 savoir qu\u2019elles sont psychosomatiques ou constituent une excuse pour s\u2019absenter du travail. Tal se souvient d’une conf\u00e9rence r\u00e9cente au cours de laquelle l’orateur principal, reconnaissant le fait r\u00e9v\u00e9lateur du long covid, s’est excus\u00e9 pour ce qu’il avait \u00e9crit dans le pass\u00e9 sur la maladie de Lyme chronique.<\/p><\/blockquote>\n\n\n\n

L’\u00e9tude M<\/strong>ucosal A<\/strong>nd systE<\/strong>mic S<\/strong>ignatures T<\/strong>riggered by R<\/strong>esponses to infectious O<\/strong>rganisms (MAESTRO<\/strong>) dont l’objectif est de faire progresser la compr\u00e9hension des maladies chroniques cons\u00e9cutives \u00e0 une infection et d’identifier de nouveaux biomarqueurs de la maladie de Lyme et du Long COVID.<\/p>\n\n\n\n

Alors que les infections \u00e0 Covid continuent d\u2019augmenter et que le changement climatique pousse les tiques vers de nouveaux habitats, d\u00e9couvrir les causes de ces maladies et trouver des rem\u00e8des deviendra de plus en plus essentiel. Sans traitement, de nombreux patients sont confront\u00e9s toute leur vie \u00e0 des sympt\u00f4mes invalidants. Tal esp\u00e8re trouver le financement n\u00e9cessaire pour \u00e9tendre MAESTRO afin d’inclure davantage de patients de plus de 65 ans, car les donn\u00e9es \u00e9pid\u00e9miologiques et leurs recherches compl\u00e9mentaires sur les souris sugg\u00e8rent que les sympt\u00f4mes s’aggravent avec l’\u00e2ge. Et l\u2019impact pourrait \u00e9galement s\u2019\u00e9tendre au-del\u00e0 des patients de longue dur\u00e9e de Covid et de Lyme. \u00ab Si nous ne faisons rien, nous allons \u00e9craser nos syst\u00e8mes de sant\u00e9 \u00bb, dit Tal, \u00ab parce qu\u2019ils ne sont pas \u00e9quip\u00e9s pour faire face \u00e0 ce niveau de maladies chroniques \u00bb.<\/p><\/blockquote>\n\n\n\n

Aussi intimidants que soient ces probl\u00e8mes, Tal reste optimiste. \u00ab\u00a0Je suis convaincue que c’est un probl\u00e8me qui peut \u00eatre r\u00e9solu\u00a0\u00bb, dit-elle. \u00ab J\u2019ai fait tout ce que je pouvais pour essayer de le trouver. Et j\u2019esp\u00e8re vraiment que nous le ferons.<\/p><\/blockquote>\n\n\n\n

https:\/\/www.technologyreview.com\/2024\/02\/28\/1087617\/tackling-long-haul-diseases\/<\/a><\/p>\n\n\n\n

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