{"id":17095,"date":"2024-11-12T20:21:48","date_gmt":"2024-11-12T19:21:48","guid":{"rendered":"https:\/\/francelyme.fr\/site\/?p=17095"},"modified":"2024-11-12T20:21:49","modified_gmt":"2024-11-12T19:21:49","slug":"des-chercheurs-autrichiens-ouvrent-une-nouvelle-voie-pour-traiter-la-borreliose-sans-antibiotiques","status":"publish","type":"post","link":"https:\/\/francelyme.fr\/site\/des-chercheurs-autrichiens-ouvrent-une-nouvelle-voie-pour-traiter-la-borreliose-sans-antibiotiques\/","title":{"rendered":"Des chercheurs autrichiens ouvrent une nouvelle voie pour traiter la borr\u00e9liose sans antibiotiques"},"content":{"rendered":"
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La borr\u00e9liose de Lyme est tr\u00e8s r\u00e9pandue en Autriche, pratiquement 10 fois plus qu\u2019en France, puisqu\u2019on y recense 70 000 nouveaux cas par an, pour une population 7,5 fois plus faible. Rappelons que les donn\u00e9es officielles en France sont de 50 000 nouveaux cas par an en moyenne ces derni\u00e8res ann\u00e9es, chiffre sans doute sous-estim\u00e9 du fait qu\u2019une grande partie des territoires ruraux n\u2019est pas r\u00e9ellement couverte par le r\u00e9seau Sentinelles.<\/p>\n\n\n\n

Une \u00e9quipe de recherche de l\u2019Universit\u00e9 de M\u00e9decine de Vienne vient de r\u00e9aliser des progr\u00e8s significatifs dans la compr\u00e9hension du m\u00e9canisme de l\u2019infection. Elle a aussi identifi\u00e9 une nouvelle voie potentiellement prometteuse pour disposer de th\u00e9rapies ne reposant pas sur des antibiotiques.<\/p>\n\n\n\n

L\u2019\u00e9quipe s\u2019est concentr\u00e9e sur un syst\u00e8me de d\u00e9fense de la bact\u00e9rie Borrelia (le \u00ab syst\u00e8me de restriction-modification \u00bb, ou RMS), qui agit comme un syst\u00e8me immunitaire primitif, prot\u00e9geant la bact\u00e9rie elle-m\u00eame contre le mat\u00e9riel g\u00e9n\u00e9tique \u00e9tranger.<\/p>\n\n\n\n

Pour comprendre comment Borrelia r\u00e9ussit \u00e0 se prot\u00e9ger au sein d\u2019un h\u00f4te, les chercheurs ont utilis\u00e9 une m\u00e9thode innovante, dans laquelle ils ont analys\u00e9 et modifi\u00e9 son ADN.<\/p>\n\n\n\n

Ils ont ainsi d\u00e9couvert qu\u2019un processus bien connu, la m\u00e9thylation de l\u2019ADN des bact\u00e9ries, qui aide normalement la bact\u00e9rie \u00e0 se prot\u00e9ger contre l\u2019ADN \u00e9tranger, peut \u00eatre utilis\u00e9 pour la d\u00e9truire.<\/p>\n\n\n\n

Cette d\u00e9couverte en apparence anodine pourrait avoir de grandes applications, car elle ouvre potentiellement de nouvelles voies de traitement sans recours aux antibiotiques, notamment par la th\u00e9rapie phagique. Cette m\u00e9thode utilise des bact\u00e9riophages, des virus qui attaquent sp\u00e9cifiquement les bact\u00e9ries, comme alternative aux antibiotiques, r\u00e9duisant ainsi le risque de r\u00e9sistance.<\/p>\n\n\n\n

Ce n\u2019est pas la premi\u00e8re fois qu\u2019on parle des bact\u00e9riophages, ces \u00ab virus mangeurs de bact\u00e9ries \u00bb : au 19\u00e8me<\/sup> si\u00e8cle et au d\u00e9but du 20\u00e8me<\/sup>, les bact\u00e9riophages \u00e9taient tr\u00e8s \u00e9tudi\u00e9s, singuli\u00e8rement en France, avant l\u2019arriv\u00e9e des antibiotiques.<\/p>\n\n\n\n

Pour en savoir plus, le lien vers la publication :<\/p>\n\n\n\n

https:\/\/www.mdpi.com\/1422-0067\/25\/21\/11343<\/a><\/p>\n\n\n

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